Alfred Hero - Interests in Bioinformatics
My interests are in reliable extraction of differential expression signals
from gene microarray data, gene clustering, and genetic networks. My primary
collaborators are Gilles Fleury at SupElec in Paris, Dr. Alan Mears at
Univ. of Ottawa, and Dr. Anand Swaroop at
the UM Kellog Eye Center.
Presentations
"In vitro measurement of gene expression, Part II: Analysis." Slides
from a tutorial given at the IEEE Intl. Symposium on Biomedical Imaging
(ISBI-04) are here
"Statistical signal processing for gene microarrays." Slides
from a plenary talk given at EUSIPCO, Vienna Austria, Sept. 2004
here
Journals
D. Zhu, A.O. Hero, Z.S. Qin, "High throughput screening of
co-expressed gene pairs with controlled False Discovery Rate (FDR) and
Minimum Acceptable Strength (MAS),"
(.pdf) , submitted to Journal of Computational Biology, Nov. 2004.
Supplemental tables: (.pdf)
.
S. Zareparsi, A.O. Hero, D.J. Zack, R. Williams, A. Swaroop, "Seeing the
Unseen: Microarray-based Gene Expression Profiling in Vision," , Journal of Investigative
Ophthalmology and Vision Research (IOVS), Oct. 2004.
S. Yoshida, A. J. Mears, J. S. Friedman, T. Carter, S. He, E. Oh,
Y. Jing, R. Farjo, G. Fleury, C. Barlow, A. O. Hero, A. Swaroop,
"Expression profiling of the developing and mature Nrl-/- mouse retina:
Identification of retinal disease candidates and transcriptional regulatory
targets of Nrl,"
(.pdf) , Human Molecular Genetics, vol. 13, no. 14, pp. 1497=1503, 2004. Supplement ,
G. Fleury, A. Hero, S. Zareparsi, and A. Swaroop, "Gene Discovery Using
Pareto Depth Sampling Distributions"
(.html)
, (.pdf)
,
Special Issue on Genomics, Signal Processing and
Statistics, Journ. of Franklin Institute, vol. 341,
No. 1-2, pp. 55-75, Jan-Mar 2004.
A. Hero, G. Fleury, A. Mears and A. Swaroop, "Multicriteria Gene
Screening for Analysis of Differential Expression with DNA
Microarrays," color version with corrections (.pdf) , journal
version (.pdf) ,
Special Issue on Genomic Signal Processing, EURASIP Journ. of
Applied Signal Processing (EURASIP JASP), vol. 2004, No. 1,
pp. 43-52, 2004. Note: the journal version has some typos: 1)
in equation (9) $\hat{\xi}(g)$ is the maximum paired t
statistic defined in previous paragraph; 2) above (9)
"...>fcmin" should be replaced by "...>f", where f is the
standard FDR significance threshold; 3) in equation (10)
$\alpha$ should be replaced by $1-(1-\alpha)^{1/3}$ (Thanks to
Jing Qiu of Cornell University for picking these typos up).
These typos have been corrected in the color version.
A. Hero and G. Fleury, "Pareto-optimal methods for gene ranking"
(.pdf)
, Journ. of VLSI Signal Processing, Special
Issue on Genomic Signal Processing, vol. 38,
pp. 259-275, 2004.
Conference Proceedings
D. Zhu and A. O. Hero, "Unsupervised posterior analysis of
signaling pathways from gene microarray data," (.pdf), submitted to
Proc. of GENSIPS , Newport RI, April 2005.
D. Zhu and A. O. Hero, "Gene co-expression network discovery with
controlled statistical and biological significance," (.pdf),
Proc. of ICASSP , Philadelphia, March, 2005.
D. Zhu and A. O. Hero, "Network constrained clustering for gene microarray data," (.pdf),
Proc. of ICASSP , Philadelphia, March, 2005.
"Pareto Depth Sampling Distributions for Gene Ranking" (.pdf) ,
G. Fleury, A. Hero, S. Zareparsi, and A. Swaroop, to appear
in Proc. of IEEE Intern, Symp. on Biomedical Imaging, April
2004.
Yu J, Mears AJ, Yoshida S, Farjo R, Carter TA, Ghosh D, Hero A, Barlow
C, Swaroop A: From disease genes to cellular pathways: A progress report (.pdf) . In "Retinal dystrophies:
functional genomics to gene therapy." Wiley, Chichester (Novartis Foundation
Sympoium 255) pp 147-164, 2004.
"Gene selection and ranking with microarray data" (.pdf) , A. Hero,
paper accompanying plenary talk. Proc. of Intl Conf on Signal Processing and
Applications, Paris, July 2003.
"Posterior Pareto front analysis for gene filtering" (.pdf) , A. Hero and
G. Fleury, Proc. of Workshop on Genomic Signal Processing
and Statistics (GENSIPS), Raleigh NC,
Oct 11-13 2002.
"Mathematical Morphology applied to Spot Segmentation and Quantification
of Gene Microarray Images", (.pdf)
, K.I. Siddiqui, A. Hero, and M. Siddiqui,
2002 Asilomar Conference on Signals and Systems, Nov. 2002.
"Clustering Gene Expression Signals from Retinal Microarray Data," (.pdf) G. Fleury,
A. Hero, S. Yoshida, T. Carter, C. Barlow and A.
Swaroop, in Proc. IEEE Int. Conf. on Acoust.,
Speech, and SIg. Process., Orlando FL, May 2002.
"Pareto analysis for gene filtering in microarray experiments," (.pdf) G. Fleury, A. Hero, S.
Yoshida, T. Carter, C. Barlow and A. Swaroop, Proc. XI
European Signal Processing Conference, Toulouse France, Sept 2002.
Conference Abstracts
Alan J. Mears, Shigeo Yoshida, James S. Friedman, Shirley He, Edwin Oh,
Gilles Fleury, Alfred O. Hero and Anand Swaroop, "Identification of the
downstream targets of Nrl: the key regulator of rod photoreceptor
differentiation," ARVO-2004.
Some bioinformatics links
Thinkquest's basic genetics tutorial Molecular genetics
A newsletter for computational genetics Human
Genome News
A peer reviewed electronic journal on bioinformatics
In Silico Biology
Y.F. Leung's site with news, glossaries, tutorials etc Functional Genomics
Oligonucleotide chips: Affymetrix
Terry Speed's
microarray
analysis website
NIH NHGRI
site
Carollee Barlow's
site
Affymetrix third party software
site
Some Bayesian Nets links
Gharamani, Z.
Learning Bayesian networks.
Scheines, R.
An Introduction to Causal Inference.
Scheines, R., Spirtes, P., Glymour, C., Meek, C., and Richardson, T.
The TETRAD Project: Constraint Based Aids to Causal Model Specification.
Tetrad Software Project Homepage.
Some general life science links
Theoretical Life Science Lab Repository.
Prof. Alfred O. Hero III
Dept. of Electrical Engineering and Computer Science
The University of Michigan
1301 Beal Avenue
Ann Arbor, MI 48109-2122
Tel. (313) 763-0564
FAX: (313) 763-8041
WWW:
http://www.eecs.umich.edu/~hero/hero.html
email: