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 The CUOS Medical group applies femtosecond pulse laser-induced phenomena to address biological questions and to develop tools to further biomedical research. Bubble-based Measurement of Tissue Elasticity The main goal of this project is to develop a new technology to measure tissue elasticity by deformation with acoustic radiation force applied to femtosecond laser produced microbubbles. More info... Speck-ectomy Femtosecond laser ablation is used to perform intracellular microsurgery, ablating apoptosis-inducing ASC speck protein aggregates, allowing infected cells to survive and undergo mitosis. This type of structural knockout is valuable in illuminating the mechanism of ASC-induced apoptosis. More info... Mitotic Forces We aim to infer the mechanics of polar ejection forces acting on chromosomes during mitosis by performing intracellular microsurgery on mitotic cells. Femtosecond laser ablation is used to cut the arms off mitotic chromosomes and their movement is tracked via reconstruction of multi-slice phase contrast microscopy images. More info coming soon... Mechanism of Optical Breakdown We are studying the physics underlying femtosecond optical breakdown in semiconductors. More info coming soon... Nano-machining Ablation by femtosecond optical breakdown at critical intensity is capable of ablating features at resolutions far exceeding the diffraction limited spot size. We have achieved features as small as 10nm in glass. Joglekar et al. (2004) PNAS. 101(16), 5856-5861 3D Microfluidics Ke, Hasselbrink, and Hunt (2005) Anal. Chem. 77(16), 5083-5088
Poster presented at 2006 University of Michigan Aging Research Symposium. |
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