Pernillo's research area is CMOS mixed-signal circuits for biochip applications, and he works with Prof. Michael Flynn. Pernillo stated, "My specific research interests are in the development and demonstration of integrated circuit techniques to facilitate controlled growth and imaging of cell cultures on a micro scale. This research involves the development of circuit techniques for imaging, analog to digital conversion and control. The techniques will enable new research in cell tissue development and disease. Furthermore since these techniques are compatible with CMOS integrated circuit technology they will facilitate cheap analysis and diagnosis."