Biophotonics is concerned with the application of optics and photonics technology to biomedical problems, as well as to fundamental biology and biophysics.
Novel photonic devices are being developed for both imaging and sensing. Fiber-based in vivo fluorescence sensors are being used to detect the dynamics of drug delivery in nanomedicine. Photonic crystal structures are being used to perform ultrahigh-sensitivity assays of biomolecular binding. Multiphoton fluorescence is being used to perform in vivo flow cytometry to study the dynamics of circulating cancer cells. Coherent control techniques are being developed to exploit the capabilities of shaped femtosecond pulses to perform selective excitation of biologically important fluorophores. Novel methods are being developed to perform fluorescence measurements simultaneously across the entire optical spectrum, thus enabling assays with many biomarkers.
Working at the level of single biomolecules, it is now possible to perform biochemical measurements at the femto-mole level, creating new opportunities for building sensors and developing new methodologies to understand the origin of molecular-based disease.
Guo, L. Jay
Islam, Mohammed N.
Norris, Theodore B.
Related Labs, Centers, and Groups
Center for Ultrafast Optical Science
Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS)
Optics and Photonics Laboratory